Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternative cleavage and polyadenylation: key regulatory mechanisms in health and disease

4 Jul 2025

Abstract excerpt

Alternative polyadenylation (APA) is a critical post-transcriptional regulatory mechanism that generates diverse mRNA isoforms by selecting different polyadenylation sites within pre-mRNAs, thereby modulating the length of the 3' untranslated region (3' UTR), thereby fine-tuning gene expression and protein synthesis. APA regulation involves conserved cis-acting elements, trans-acting factors, and key protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eosinophilic Esophagitis
Share to IL-33, ST2, and ILC Pathways
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40613493
DOI: 10.1080/15476286.2025.2529033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternative cleavage and polyadenylation: key regulatory mechanisms in health and diseasePMID 40613493Read ↗

A compendium of conserved cleavage and polyadenylation events in mammalian genes.Semantic proximity Read ↗

Systematic identification of functional SNPs interrupting 3’ UTR polyadenylation signalsSemantic proximity Read ↗

Analysis of alternative cleavage and polyadenylation in mature and differentiating neurons using RNA‐seq dataSemantic proximity Read ↗

Systematic identification of functional SNPs interrupting 3'UTR polyadenylation signals.Semantic proximity Read ↗

APAlyzer: a bioinformatics package for analysis of alternative polyadenylation isoformsSemantic proximity Read ↗

Large-scale alternative polyadenylation (APA)-wide association studies to identify putative susceptibility genes in human common cancersSemantic proximity Read ↗

Single-cell alternative polyadenylation analysis reveals mechanistic insights of COVID-19-associated neurological and psychiatric effectsSemantic proximity Read ↗

Alternative polyadenylation-associated loci interpret human traits and diseases.Semantic proximity Read ↗

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disordersSemantic proximity Read ↗

Identification and quantification of alternative polyadenylation sites in single cell RNA-seq data using scPAISOSemantic proximity Read ↗

Genetic Basis of Alternative Polyadenylation is an Emerging Molecular Phenotype for Human Traits and DiseasesSemantic proximity Read ↗

A comprehensive analysis of 3’ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogenous ribonucleoprotein C on cleavage and polyadenylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.