Article

Protein-only centromeric chromatin assembly streamlines human artificial chromosome formation

2026-01-29

Abstract excerpt

Human artificial chromosomes (HACs) are inherited through cell divisions alongside natural chromosomes, serving as tools for interrogating chromosomal elements and as vectors for large genetic cargoes ( 1–5 ). Despite recent progress ( 6–8 ), large (i.e., multiple Mb) HACs have not been reported. Further, HAC formation via epigenetic seeding of centromeric chromatin currently requires prior engineering of recipi...

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Literature Corpus work: dd3cde20-532e-56b4-966a-1ba62c0f2fd1
DOI: 10.64898/2026.01.28.702397

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