Article

Higher-order assembly is a regulatory switch that promotes outer kinetochore recruitment

2023-05-22

Abstract excerpt

<h4>Summary</h4> To faithfully segregate chromosomes during vertebrate mitosis, kinetochore-microtubule interactions must be restricted to a single site on each chromosome. Prior work on pair-wise kinetochore protein interactions has been unable to identify the mechanisms that prevent kinetochore formation in regions with a low density of CENP-A nucleosomes. To investigate the impact of higher-order assembly on k...

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Literature Corpus work: afcc03a2-94ed-5008-ae8f-d392094fdf0e
DOI: 10.1101/2023.05.22.541649

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