Article

Rapid assembly of functional modules for generating human artificial chromosome constructs compatible with epigenetic centromere seeding

2025-10-03

Abstract excerpt

The ongoing development of human artificial chromosomes (HACs) will permit investigation into essential centromere processes and the means to deliver large genetic cargoes to target cells. Starting with large (∼750 kb) yeast artificial chromosome (YAC)-based constructs limits the rampant multimerization that has complicated many prior types of HACs. Large YAC construction is accomplished using transformation-assoc...

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Literature Corpus work: 550a6eb7-ed45-55fc-b8ec-919ce6f2cb2f
DOI: 10.1101/2025.10.02.680129

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