Article

Epigenetic inheritance of centromere identity in a heterologous system

2019-02-25

Abstract excerpt

<h4>SUMMARY</h4> The centromere is an essential chromosomal region required for accurate chromosome segregation. Most eukaryotic centromeres are defined epigenetically by the histone H3 variant, CENP-A, yet how its self-propagation is achieved remains poorly understood. Here we developed a heterologous system to reconstitute epigenetic inheritance of centromeric chromatin by ectopically targeting the Drosophila...

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Literature Corpus work: ae0a4b92-3f47-5d1c-b919-7f408a2c4bea
DOI: 10.1101/560391

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