Article

Ablation and Seed-driven Restoration of an Alpha-Satellite Devoid Human Centromere Reveals Size Homeostasis Mechanisms

2026-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Human centromeres are epigenetically defined chromatin domains marked by nucleosomes containing the histone H3 variant CENP-A, which recruit the constitutive centromere-associated network (CCAN) to assemble functional kinetochores. Maintaining centromere function, including chromatin domain size and the ability to assemble the kinetochore, is essential for proper mitotic division across eukaryot...

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Literature Corpus work: e65b39ef-f165-53cf-960a-e7c735385bbe
DOI: 10.64898/2026.08.14.744943

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