Article

Centromere inactivation during aging can be rescued in human cells

2023-12-30

Abstract excerpt

<h4>Summary</h4> Aging involves a range of genetic, epigenetic, and physiological alterations. A key characteristic of aged cells is the loss of global heterochromatin, accompanied by a reduction in canonical histone levels. In this study, we track the fate of centromeres during aging in human cells. Our findings reveal that the centromeric histone H3 variant CENP-A is downregulated in aged cells, in a p53-depend...

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Literature Corpus work: bfd2e420-1647-51c2-b6aa-a91831a325df
DOI: 10.1101/2023.12.30.573721

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