Article

Analysis of Complex DNA Rearrangements During Early Stages of HAC Formation

2020-07-03

Abstract excerpt

Human Artificial Chromosomes (HACs) are important tools for epigenetic engineering, for measuring chromosome instability (CIN) and possible gene therapy. However, their use in the latter is potentially limited because the input HAC-seeding DNA can undergo an unpredictable series of rearrangements during HAC formation. As a result, after transfection and HAC formation, each cell clone contains a HAC with a unique s...

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Literature Corpus work: 1d1d30d7-709a-5642-a857-b0252a8debff
DOI: 10.1101/2020.07.02.184408

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