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Article

The quantitative architecture of centromeric chromatin.

eLife - 15 Jul 2014

Bodor Dani L, Mata João F, Sergeev Mikhail, David Ana Filipa, Salimian Kevan J, Panchenko Tanya, Cleveland Don W, Black Ben E, Shah Jagesh V, Jansen Lars Et

Abstract excerpt

The centromere, responsible for chromosome segregation during mitosis, is epigenetically defined by CENP-A containing chromatin. The amount of centromeric CENP-A has direct implications for both the architecture and epigenetic inheritance of centromeres. Using complementary strategies, we determined that typical human centromeres contain ∼400 molecules of CENP-A, which is controlled by a mass-action mechanism....

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Identifiers

PMID: 25027692
DOI: 10.7554/eLife.02137
PMCID: PMC4091408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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