Article

Expansion of human centromeric arrays in cells undergoing break-induced replication

2023-11-15

Abstract excerpt

Human centromeres are located within α-satellite arrays and evolve rapidly, which can lead to individual variation in array lengths. Proposed mechanisms for such alterations in lengths are unequal cross-over between sister chromatids, gene conversion, and break-induced replication. However, the underlying molecular mechanisms responsible for the massive, complex, and homogeneous organization of centromeric arrays...

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Literature Corpus work: c05b301c-a50d-5ae4-8088-15ec3d3884a2
DOI: 10.1101/2023.11.11.566714

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