Article

Human centromere formation activates transcription and opens chromatin fibre structure

2022-01-18

Abstract excerpt

<title>Abstract</title> <p>Human centromeres appear as constrictions on mitotic chromosomes and form a platform for kinetochore assembly in mitosis. Biophysical experiments led to a suggestion that repetitive DNA at centromeric regions form a compact scaffold necessary for function, but this was revised when neocentromeres were discovered on non-repetitive DNA. To test whether centromeres have a special chromatin...

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Literature Corpus work: 5c36d0fa-9f86-5ab7-a0a2-9a4be7f1f010
DOI: 10.21203/rs.3.rs-1061218/v1

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