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Article

Functional complementation of a genetic deficiency with human artificial chromosomes.

American journal of human genetics - 1 Aug 2001

Mejía J E, Willmott A, Levy E, Earnshaw W C, Larin Z

Abstract excerpt

We have shown functional complementation of a genetic deficiency in human cultured cells, using artificial chromosomes derived from cloned human genomic fragments. A 404-kb human-artificial-chromosome (HAC) vector, consisting of 220 kb of alphoid DNA from the centromere of chromosome 17, human telomeres, and the hypoxanthine guanine phosphoribosyltransferase (HPRT) genomic locus, was transferred to HPRT-deficient...

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Identifiers

PMID: 11452360
DOI: 10.1086/321977
PMCID: PMC1235305

Genes

HPRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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