Article

Large-scale statistical mapping of T-cell receptor <i>β</i> sequences to Human Leukocyte Antigens

2024-04-02

Abstract excerpt

T-cell receptors (TCRs) interacting with peptides presented by human leukocyte antigens (HLAs) are the foundation of the adaptive immune system but population-level analysis of TCR-HLA interactions is lacking. Here we statistically associate ∼ 10 6 public TCRs to specific HLAs using the TCR β repertoires sampled from 4,144 HLA-genotyped subjects. The TCRs we associate are specific to unique HLA allotypes, not a...

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Literature Corpus work: dd3106b1-a0ad-54f7-ae57-8eb7721a37a2
DOI: 10.1101/2024.04.01.587617

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