Article

Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity

2018-05-02

Abstract excerpt

The T cell receptor (TCR) repertoire encodes immune exposure history through the dynamic formation of immunological memory. Statistical analysis of repertoire sequencing data has the potential to decode disease associations from large cohorts with measured phenotypes. However, the repertoire perturbation induced by a given immunological challenge is conditioned on genetic background via major histocompatibility co...

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Literature Corpus work: 03a79f43-a48c-5ed3-959e-9b5839316149
DOI: 10.1101/313106

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