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Article

T cell receptor clonotypes predict human leukocyte antigen allele carriage and antigen exposure history.

Communications biology - 13 Jan 2026

ElAbd Hesham, Mahdy Aya K H, Wacker Eike Matthias, Gretsova Maria, Ellinghaus David, Dempfile Astrid, Franke Andre

Abstract excerpt

Conventional T cells recognize peptides presented by the human leukocyte antigen (HLA) proteins through their T cell receptors (TCRs). Given that thousands of HLA proteins have been discovered, each presenting thousands of different peptides, decoding the cognate HLA protein of a TCR experimentally is a challenging task. To address this problem, we combined statistical learning methods with a unique dataset of...

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PMID: 41530431
DOI: 10.1038/s42003-025-09140-2
PMCID: PMC12800166

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TRA
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