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The digital keystone: how artificial intelligence is reshaping HLA research and clinical practice.

Immunogenetics - 27 Apr 2026

Sonmez Gamze, Yazarkan Yigit, Cagdas Deniz

Abstract excerpt

The human leukocyte antigen (HLA) system underpins allorecognition and shapes the response to infection, autoimmunity, and treatment response. Technological advances from serology to next-generation sequencing now enable full-gene characterization and four-field HLA nomenclature, while artificial intelligence (AI) and machine learning are transforming the data generation, interpretation, and clinical use. This...

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PMID: 42043567
DOI: 10.1007/s00251-026-01397-z
PMCID: PMC13121240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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