Article

Learning predictive signatures of HLA type from T-cell repertoires

2024-01-29

Abstract excerpt

T cells recognize a wide range of pathogens using surface receptors that interact directly with pep-tides presented on major histocompatibility complexes (MHC) encoded by the HLA loci in humans. Understanding the association between T cell receptors (TCR) and HLA alleles is an important step towards predicting TCR-antigen specificity from sequences. Here we analyze the TCR alpha and beta repertoires of large cohor...

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Literature Corpus work: 7f9d93b3-dfb4-5976-b15a-1e10094f45f4
DOI: 10.1101/2024.01.25.577228

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