Article

Decoding the restriction of T cell receptors to human leukocyte antigen alleles using statistical learning

2025-02-08

Abstract excerpt

Conventional T cells recognize peptides presented by the human leukocyte antigen (HLA) proteins through their T cell receptors (TCRs). Given that thousands of HLA proteins have been discovered, each presenting thousands of different peptide antigens, decoding the cognate HLA protein of a TCR experimentally is a challenging task. To address this problem, we combined statistical learning methods with a unique datase...

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Literature Corpus work: ee4a1b0a-0773-57c3-bac9-d901d2eec1e1
DOI: 10.1101/2025.02.06.636910

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