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Article

Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity.

eLife - 28 Aug 2018

DeWitt William S, Smith Anajane, Schoch Gary, Hansen John A, Matsen Frederick A, Bradley Philip

Abstract excerpt

The T cell receptor (TCR) repertoire encodes immune exposure history through the dynamic formation of immunological memory. Statistical analysis of repertoire sequencing data has the potential to decode disease associations from large cohorts with measured phenotypes. However, the repertoire perturbation induced by a given immunological challenge is conditioned on genetic background via major histocompatibility...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30152754
DOI: 10.7554/eLife.38358
PMCID: PMC6162092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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