Article
TCR2HLA: Calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes.
PLoS computational biology - 1 Jan 2026
Mayer-Blackwell Koshlan, Minervina Anastasia, Pogorelyy Mikhail, Rawat Puneet, Shapiro Melanie R, Peters Leeana D, Ford Emily S, Posgai Amanda L, Vegesana Kasi, Minot Samuel, Koelle David M, Greiff Victor, Bradley Philip, Brusko Todd M, Thomas Paul G, Fiore-Gartland Andrew
Abstract excerpt
T cell receptors (TCRs) recognize peptides presented by polymorphic human leukocyte antigen (HLA) molecules, but HLA genotype data are often missing from TCR repertoire sequencing studies. To address this, we developed TCR2HLA, an open-source tool that infers HLA genotypes from TCRβ repertoires. Expanding on work linking public TRBV-CDR3 sequences to HLA genotypes, we incorporated "quasi-public" metaclonotypes -...
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