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Article

Learning predictive signatures of HLA type from T-cell repertoires.

PLoS computational biology - 1 Jan 2025

Ruiz Ortega María, Pogorelyy Mikhail V, Minervina Anastasia A, Thomas Paul G, Mora Thierry, Walczak Aleksandra M

Abstract excerpt

T cells recognize a wide range of pathogens using surface receptors that interact directly with peptides presented on major histocompatibility complexes (MHC) encoded by the HLA loci in humans. Understanding the association between T cell receptors (TCR) and HLA alleles is an important step towards predicting TCR-antigen specificity from sequences. Here we analyze the TCR alpha and beta repertoires of large...

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Topics

Humans
HLA Antigens
Computational Biology
T-Lymphocytes
Alleles
Receptors, Antigen, T-Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell, alpha-beta

Source

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Identifiers

PMID: 39761303
DOI: 10.1371/journal.pcbi.1012724
PMCID: PMC11737854

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