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Article

Exploration of the roles of HLAs when predicting infection status by T cell receptors.

Scientific reports - 28 Oct 2025

Ding Feng, Liu Si, Sun Wei

Abstract excerpt

T cells are critical components of the human immune system. When a cell is infected by a virus, it presents viral peptides on its surface using human leukocyte antigen (HLA) proteins. These peptide-HLA complexes are recognized by T cells through interactions with T cell receptors (TCRs). A human blood sample can contain millions of unique TCRs, which is a sample from the individual's TCR repertoire. TCR...

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Identifiers

PMID: 41152450
DOI: 10.1038/s41598-025-21453-0
PMCID: PMC12568941

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