Article

TCR2HLA: calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes

2025-07-23

Abstract excerpt

T cell receptors (TCRs) recognize peptides presented by polymorphic human leukocyte antigen (HLA) molecules, but HLA genotype data are often missing from TCR repertoire sequencing studies. To address this, we developed TCR2HLA, an open-source tool that infers HLA genotypes from TCRβ repertoires. Expanding on work linking public TRBV-CDR3 sequences to HLA genotypes, we incorporated “quasi-public” metaclonotypes – c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa37cc21-4d6f-5f04-bae3-6536587e8df1
DOI: 10.1101/2025.07.18.665436

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TCR2HLA: calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypesDOI 10.1101/2025.07.18.665436Read

TCR2HLA: Calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes.Semantic proximity Read

TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs.Semantic proximity Read

TCR meta-clonotypes for biomarker discovery with tcrdist3: identification of public, HLA-restricted SARS-CoV-2 associated TCR featuresSemantic proximity Read

Exploration of the Roles of HLAs When Predicting Infection Status by T Cell ReceptorsSemantic proximity Read

BenchRep-T: A Systematic Evaluation of T-Cell Repertoire-Based Disease DiagnosticsSemantic proximity Read

Large-scale statistical mapping of T-cell receptor <i>β</i> sequences to Human Leukocyte AntigensSemantic proximity Read

Exploration of the roles of HLAs when predicting infection status by T cell receptors.Semantic proximity Read

T cell receptor clonotypes predict human leukocyte antigen allele carriage and antigen exposure history.Semantic proximity Read

Benchmarking unsupervised methods for inferring TCR specificitySemantic proximity Read

Immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donorsSemantic proximity Read

Decoding the restriction of T cell receptors to human leukocyte antigen alleles using statistical learningSemantic proximity Read

Disease associated human TCR characterization by deep-learning framework TCR-DeepInsightSemantic proximity Read