Article

Image-based identification and isolation of micronucleated cells to dissect cellular consequences

2023-05-05

Abstract excerpt

Recent advances in isolating cells based on visual phenotypes have transformed our ability to identify the mechanisms and consequences of complex traits. Micronucleus (MN) formation is a frequent outcome of genome instability, triggers extensive changes in genome structure and signaling coincident with MN rupture, and is almost exclusively defined by visual analysis. Automated MN detection in microscopy images has...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd211629-ad6c-54d2-8744-911b63972975
DOI: 10.1101/2023.05.04.539483

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Image-based identification and isolation of micronucleated cells to dissect cellular consequencesDOI 10.1101/2023.05.04.539483Read

micronuclAI: Automated quantification of micronuclei for assessment of chromosomal instabilitySemantic proximity Read

Chromothripsis from DNA damage in micronuclei.Semantic proximity Read

Sequencing Micronuclei Reveals the Landscape of Chromosomal InstabilitySemantic proximity Read

Epigenetic dysregulation from chromosomal transit in micronucleiSemantic proximity Read

The proteomic landscape of genotoxic stress-induced micronucleiSemantic proximity Read

ER-directed TREX1 limits cGAS recognition of micronucleiSemantic proximity Read

Small but strong: Mutational and functional landscapes of micronuclei in cancer genomes.Semantic proximity Read

Nuclear envelope assembly defects link mitotic errors to chromothripsisSemantic proximity Read

Extrachromosomal DNA micronucleation constrains tumour fitness and improves patient survivalSemantic proximity Read

A Single Defined Sister Chromatid Fusion Destabilizes Cell Cycle through Micronuclei FormationSemantic proximity Read

The phenotypic landscape of essential human genes.Semantic proximity Read

Chromosome length and gene density contribute to micronuclear membrane stabilitySemantic proximity Read