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Article

Chromothripsis from DNA damage in micronuclei.

Nature - 11 Jun 2015

Zhang Cheng-Zhong, Spektor Alexander, Cornils Hauke, Francis Joshua M, Jackson Emily K, Liu Shiwei, Meyerson Matthew, Pellman David

Abstract excerpt

Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromothripsis is unknown, but we previously proposed that it could occur through the physical isolation...

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Source

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Identifiers

PMID: 26017310
DOI: 10.1038/nature14493
PMCID: PMC4742237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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