Article

ER-directed TREX1 limits cGAS recognition of micronuclei

2020-05-20

Abstract excerpt

<h4>ABSTRACT</h4> Chromosomal instability in cancer results in the formation of nuclear aberrations termed micronuclei. Spontaneous loss of micronuclear envelope integrity exposes DNA to the cytoplasm, leading to chromosome fragmentation and innate immune activation. Despite connections to cancer genome evolution and anti-tumor immunity, the mechanisms underlying damage and immune sensing of micronuclear DNA are...

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Identifiers and source

Literature Corpus work: 59dc9426-9e76-5893-a854-ca266883dd61
DOI: 10.1101/2020.05.18.102103

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