Article

A Single Defined Sister Chromatid Fusion Destabilizes Cell Cycle through Micronuclei Formation

2019-04-12

Abstract excerpt

Chromosome fusion is deleterious among oncogenic chromosome rearrangements, and has been proposed to cause multiple tumor-driving abnormalities. Conventional methodologies, however, lack the strictness of the experimental controls on the fusion such as the exact timing, the number and the types of fusion in a given cell. Here, we developed a human cell-based sister chromatid fusion visualization system (FuVis), in...

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Literature Corpus work: 913b1992-a67d-5bdb-b1a9-fb72eec93003
DOI: 10.1101/607341

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