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Article

The phenotypic landscape of essential human genes.

Cell - 23 Nov 2022

Funk Luke, Su Kuan-Chung, Ly Jimmy, Feldman David, Singh Avtar, Moodie Brittania, Blainey Paul C, Cheeseman Iain M

Abstract excerpt

Understanding the basis for cellular growth, proliferation, and function requires determining the roles of essential genes in diverse cellular processes, including visualizing their contributions to cellular organization and morphology. Here, we combined pooled CRISPR-Cas9-based functional screening of 5,072 fitness-conferring genes in human HeLa cells with microscopy-based imaging of DNA, the DNA damage...

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Identifiers

PMID: 36347254
DOI: 10.1016/j.cell.2022.10.017
PMCID: PMC10482496

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