Article

Epigenetic dysregulation from chromosomal transit in micronuclei

2022-01-12

Abstract excerpt

Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers [1-4], yet whether they are mechanistically linked is unknown. Here we show that missegregation of mitotic chromosomes, their sequestration in micronuclei [5, 6], and subsequent micronuclear envelope rupture [7] profoundly disrupt normal histone post-translational modifications (PTMs), a phenomenon conse...

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Literature Corpus work: 0569a8fa-097d-5960-a78f-a3d5bde6d485
DOI: 10.1101/2022.01.12.475944

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