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Article

Small but strong: Mutational and functional landscapes of micronuclei in cancer genomes.

International journal of cancer - 15 Feb 2021

Guo Xihan, Dai Xueqin, Wu Xue, Cao Neng, Wang Xu

Abstract excerpt

Micronuclei, small spatially-separated, nucleus-like structures, are a common feature of human cancer cells. There are considerable heterogeneities in the sources, structures and genetic activities of micronuclei. Accumulating evidence suggests that micronuclei and main nuclei represent separate entities with respect to DNA replication, DNA damage sensing and repairing capacity because micronuclei are not...

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PMID: 32949152
DOI: 10.1002/ijc.33300

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