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Extrachromosomal DNA micronucleation constrains tumour fitness and improves patient survival

2025-04-18

Abstract excerpt

Extrachromosomal DNA (ecDNA) contributes to cancer genome instability by enabling high-copy oncogene amplification, intratumoural heterogeneity and rapid genetic change. Micronuclei (MN) are frequently observed in chromosomally unstable cancers, yet their origins and relevance in ecDNA-driven tumours remain incompletely understood. Here, we investigate the relationship between ecDNA segregation errors and MN forma...

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Literature Corpus work
73d87a5d-2fe0-5f32-bdd1-bc9331405d2e
DOI
10.1101/2025.04.15.648906
Open publication

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Extrachromosomal DNA micronucleation constrains tumour fitness and improves patient survivalDOI 10.1101/2025.04.15.648906
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