Article

Chromosome length and gene density contribute to micronuclear membrane stability

2021-05-14

Abstract excerpt

Micronuclei are derived from missegregated chromosomes and frequently lose membrane integrity, leading to DNA damage, innate immune activation, and metastatic signaling. Here we demonstrate that two characteristics of the trapped chromosome, length and gene density, are key contributors to micronuclei membrane stability in human cells. Chromosome length is proportional to micronuclei size, and gene density has an...

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Literature Corpus work: 5c0acf3a-09fe-5be6-ab00-0fbd6cfbe44e
DOI: 10.1101/2021.05.12.443914

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