Article

The proteomic landscape of genotoxic stress-induced micronuclei

2023-08-27

Abstract excerpt

<h4>SUMMARY</h4> Micronuclei (MN) are induced by various genotoxic stressors and amass nuclear- and cytoplasmic-resident proteins, priming the cell for MN-driven signalling cascades. Here, we measure the proteome of micronuclear, cytoplasmic, and nuclear fractions from human cells exposed to a panel of six genotoxins, comprehensively profiling their MN protein landscape. We find that MN assemble a proteome distin...

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Literature Corpus work: 09f328b7-9171-527c-ac88-07d9b89e1527
DOI: 10.1101/2023.08.27.555027

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