Article

Nuclear envelope assembly defects link mitotic errors to chromothripsis

2018-02-11

Abstract excerpt

Defects in the architecture or integrity of the nuclear envelope (NE) are associated with a variety of human diseases 1 . Micronuclei, one common nuclear aberration, are an origin for chromothripsis 2,3 , a catastrophic mutational process commonly observed in cancer genomes and other contexts 4-6 . Micronuclei have a defective NE, with the extensive chromosome fragmentation that generates chromothripsis occurri...

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Literature Corpus work: 854384cd-5d30-5ba6-a225-9afd37f05779
DOI: 10.1101/263392

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