Article

Sequencing Micronuclei Reveals the Landscape of Chromosomal Instability

2021-10-29

Abstract excerpt

Genome instability (GIN) is a main contributing factor to congenital and somatic diseases, but its sporadic occurrence in individual cell cycles makes it difficult to study mechanistically. One profound manifestation of GIN is the formation of micronuclei (MN), the engulfment of chromosomes or chromosome fragments in their own nuclear structures separate from the main nucleus. Here, we developed MN-seq, an approac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5b4daf77-fe81-58cf-9ad8-226ddc5812e0
DOI: 10.1101/2021.10.28.466311

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sequencing Micronuclei Reveals the Landscape of Chromosomal InstabilityDOI 10.1101/2021.10.28.466311Read

A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice.Semantic proximity Read

Chromothripsis from DNA damage in micronuclei.Semantic proximity Read

Genetic determinants of micronucleus formation in vivo.Semantic proximity Read

Small but strong: Mutational and functional landscapes of micronuclei in cancer genomes.Semantic proximity Read

Image-based identification and isolation of micronucleated cells to dissect cellular consequencesSemantic proximity Read

Epigenetic dysregulation from chromosomal transit in micronucleiSemantic proximity Read

Mutational signature catalogue <i>(MUSIC)</i> of DNA double-strand break repairSemantic proximity Read

The genomic characteristics and cellular origin of chromothripsis.Semantic proximity Read

MEGA dPCR reveals chromosomal aberrations, NHEJ precise repair, recurrent nuclease cleavage and DSB half-lifeSemantic proximity Read

Pervasive lesion segregation shapes cancer genome evolutionSemantic proximity Read

Extrachromosomal DNA micronucleation constrains tumour fitness and improves patient survivalSemantic proximity Read

A mutational scar-based genome-wide map of DNA double-strand break repair.Semantic proximity Read