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Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease

2024-08-01

Abstract excerpt

<title>Abstract</title> Sporadic early-onset Alzheimer’s disease (sEOAD) represents a significant but less-studied subtype of Alzheimer’s disease (AD). Here, we generated a single-nucleus multiome atlas derived from the postmortem prefrontal cortex, entorhinal cortex, and hippocampus of nine individuals with or without sEOAD. Comprehensive analyses were conducted to delineate cell type-specific transcriptomic...

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Literature Corpus work: dc68332d-9079-5cd4-ada5-aa1864c48d62
DOI: 10.21203/rs.3.rs-4622123/v1

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