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Integrative single-nucleus multi-omics analysis prioritizes candidate <i>cis</i> and <i>trans</i> regulatory networks and their target genes in Alzheimer’s disease brains

2023-05-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The genetic underpinnings of late-onset Alzheimer’s disease (LOAD) are yet to be fully elucidated. Although numerous LOAD-associated loci have been discovered, the causal variants and their target genes remain largely unknown. Since the brain is composed of heterogenous cell subtypes, it is imperative to study the brain on a cell subtype specific level to explore the biologi...

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Literature Corpus work: 852d79fe-7ce9-531e-a803-04861f67e92f
DOI: 10.1101/2023.05.12.540037

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