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Single-cell transcriptomic analysis elucidates APOE genotype specific changes across cell types in two brain regions in Alzheimer’s disease

2021-03-15

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s Disease (AD) is a complex neurodegenerative disease that gravely affects patients and imposes an immense burden on caregivers. Apolipoprotein E4 (APOE4) has been identified as the most common genetic risk factor for AD, yet the molecular mechanisms connecting APOE4 to AD are not well understood. Past transcriptomic analyses in AD have revealed APOE genotype-specific transcri...

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Literature Corpus work: effb1a34-55c8-58a7-b2db-a672bb06695e
DOI: 10.21203/rs.3.rs-291648/v1

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