Article

Single-nucleus multiome analysis of human cerebellum in Alzheimer’s disease-related dementia

2024-08-16

Abstract excerpt

<title>Abstract</title> <p>Although human cerebellum is known to be neuropathologically impaired in Alzheimer’s disease (AD) and AD-related dementias (ADRD), the cell type-specific transcriptional and epigenomic changes that contribute to this pathology are not well understood. Here, we report single-nucleus multiome (snRNA-seq and snATAC-seq) analysis of 103,861 nuclei isolated from cerebellum from 9 human cases...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f7ca705-d4a8-5c0d-b9f6-193a42a2a6af
DOI: 10.21203/rs.3.rs-4871032/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-nucleus multiome analysis of human cerebellum in Alzheimer’s disease-related dementiaDOI 10.21203/rs.3.rs-4871032/v1Read

Genomic and epigenomic insights into purkinje and granule neurons in Alzheimer’s disease and related dementia using single-nucleus multiome analysisSemantic proximity Read

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's diseaseSemantic proximity Read

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer’s diseaseSemantic proximity Read

SingleBrain: A Meta-Analysis of Single-Nucleus eQTLs Linking Genetic Risk to Brain DisordersSemantic proximity Read

Single-nucleus multi-omics of Parkinson’s disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networksSemantic proximity Read

Integrative single-nucleus multi-omics analysis prioritizes candidate <i>cis</i> and <i>trans</i> regulatory networks and their target genes in Alzheimer’s disease brainsSemantic proximity Read

Integrative single-nucleus multi-omics analysis prioritizes candidate cis and trans regulatory networks and their target genes in Alzheimer’s disease brainsSemantic proximity Read

A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders.Semantic proximity Read

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.Semantic proximity Read

Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomicsSemantic proximity Read

Integrative analysis of single-nucleus RNA sequencing and Mendelian randomization to explore novel risk genes for Alzheimer's disease.Semantic proximity Read

A Single-cell and Spatial RNA-seq Database for Alzheimer’s Disease (ssREAD)Semantic proximity Read