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Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer’s disease

2024-06-29

Abstract excerpt

Sporadic early-onset Alzheimer’s disease (sEOAD) represents a significant but less-studied subtype of Alzheimer’s disease (AD). Here, we generated a single-nucleus multiome atlas derived from the postmortem prefrontal cortex, entorhinal cortex, and hippocampus of nine individuals with or without sEOAD. Comprehensive analyses were conducted to delineate cell type-specific transcriptomic changes and linked candidate...

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Literature Corpus work: 96cf6dd0-69c2-569d-aa94-8b71164d8316
DOI: 10.1101/2024.06.25.600720

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