Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative single-nucleus multi-omics analysis prioritizes candidate cis and trans regulatory networks and their target genes in Alzheimer’s disease brains

3 Oct 2023

Abstract excerpt

BACKGROUND: The genetic underpinnings of late-onset Alzheimer's disease (LOAD) are yet to be fully elucidated. Although numerous LOAD-associated loci have been discovered, the causal variants and their target genes remain largely unknown. Since the brain is composed of heterogenous cell subtypes, it is imperative to study the brain on a cell subtype specific level to explore the biological processes underlying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neurogenesis and neuroplasticity mechanisms
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37789374
DOI: 10.1186/s13578-023-01120-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative single-nucleus multi-omics analysis prioritizes candidate cis and trans regulatory networks and their target genes in Alzheimer’s disease brainsPMID 37789374Read ↗

Integrative single-nucleus multi-omics analysis prioritizes candidate <i>cis</i> and <i>trans</i> regulatory networks and their target genes in Alzheimer’s disease brainsSemantic proximity Read ↗

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer’s diseaseSemantic proximity Read ↗

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's diseaseSemantic proximity Read ↗

Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific <i>cis</i> regulatory elementsSemantic proximity Read ↗

Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brainsSemantic proximity Read ↗

Single-nucleus multi-omics of Parkinson’s disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networksSemantic proximity Read ↗

Single-cell epigenomic identification of inherited risk loci in Alzheimer’s and Parkinson’s diseaseSemantic proximity Read ↗

Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia statesSemantic proximity Read ↗

SingleBrain: A Meta-Analysis of Single-Nucleus eQTLs Linking Genetic Risk to Brain DisordersSemantic proximity Read ↗

Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states.Semantic proximity Read ↗

Extensive profiling of transcription factors in postmortem brains defines genomic occupancy in disease-relevant cell types and links TF activities to neuropsychiatric disordersSemantic proximity Read ↗

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.