Article

Cell type-specific enhancer-promoter connectivity maps in the human brain and disease risk association

2019-09-22

Abstract excerpt

Unique cell type-specific patterns of activated enhancers can be leveraged to interpret non-coding genetic variation associated with complex traits and diseases such as neurological and psychiatric disorders. Here, we have defined active promoters and enhancers for major cell types of the human brain. Whereas psychiatric disorders were primarily associated with regulatory regions in neurons, idiopathic Alzheimer’s...

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Literature Corpus work: 96cfadf5-0bb7-5d4c-957a-943ce008acd3
DOI: 10.1101/778183

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