Article

Single-cell multiomics reveals disrupted glial gene regulatory programs in Alzheimer’s disease via interpretable machine learning

2025-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Recent development of single-cell technology across multiple omics platforms has provided new ways to obtain holistic views of cells to study disease pathobiology. Alzheimer’s disease (AD) is the most common form of dementia worldwide, yet the detailed understanding of its cellular and molecular mechanisms remains limited. In this study, we analyzed paired single-cell transcriptomic (scRNA-seq)...

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Literature Corpus work: 93807956-0411-5b51-bda7-b4493f40ad8c
DOI: 10.1101/2025.03.14.643349

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