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Article

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.

Nature neuroscience - 1 Dec 2019

Grubman Alexandra, Chew Gabriel, Ouyang John F, Sun Guizhi, Choo Xin Yi, McLean Catriona, Simmons Rebecca K, Buckberry Sam, Vargas-Landin Dulce B, Poppe Daniel, Pflueger Jahnvi, Lister Ryan, Rackham Owen J L, Petretto Enrico, Polo Jose M

Abstract excerpt

There is currently little information available about how individual cell types contribute to Alzheimer's disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex samples from control and Alzheimer's disease brains (n = 6 per group), yielding a total of 13,214 high-quality nuclei. We detail cell-type-specific gene expression patterns, unveiling how transcriptional changes in specific cell...

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PMID: 31768052
DOI: 10.1038/s41593-019-0539-4

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