Article

Comparative gene regulatory networks modulating <i>APOE</i> expression in microglia and astrocytes

2024-04-20

Abstract excerpt

<h4>Background</h4> Single-cell technologies have unveiled various transcriptional states in different brain cell types. Transcription factors (TFs) regulate the expression of related gene sets, thereby controlling these diverse expression states. Apolipoprotein E ( APOE ), a pivotal risk-modifying gene in Alzheimer’s disease (AD), is expressed in specific glial transcriptional states associated with AD. However...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 89b47361-0810-5f6e-ae86-7d13250ac724
DOI: 10.1101/2024.04.19.24306098

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative gene regulatory networks modulating <i>APOE</i> expression in microglia and astrocytesDOI 10.1101/2024.04.19.24306098Read

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's diseaseSemantic proximity Read

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer’s diseaseSemantic proximity Read

Integrative genomic and transcriptomic analysis identifies microglia-expressed genes with causal links to Alzheimer's disease risk.Semantic proximity Read

Cell type-specific enhancer-promoter connectivity maps in the human brain and disease risk associationSemantic proximity Read

Genetics of the human microglia regulome refines Alzheimer’s disease risk lociSemantic proximity Read

Regulatory landscape of Alzheimer’s disease variants in human microgliaSemantic proximity Read

The <i>APOE</i> isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s diseaseSemantic proximity Read

A single cell brain atlas in human Alzheimer’s diseaseSemantic proximity Read

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.Semantic proximity Read

A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signatureSemantic proximity Read

Alzheimer's disease transcriptional landscape in ex-vivo human microgliaSemantic proximity Read

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s diseaseSemantic proximity Read