Article

Early neuronal reprogramming and cell cycle reentry shape Alzheimer’s disease progression

2025-06-06

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by hallmark pathologies, synaptic dysfunction, neuronal loss, gliosis and cognitive decline-dementia. Recent large-scale cell atlases of human AD brains exposed vulnerability of specific neuronal subtypes and highlighted early, coordinated glial responses, suggesting glial involvement in disease progression. However, the timing and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: adda44e8-4794-59fb-8a15-c4a3e79604fa
DOI: 10.1101/2025.06.04.653670

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early neuronal reprogramming and cell cycle reentry shape Alzheimer’s disease progressionDOI 10.1101/2025.06.04.653670Read

Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolutionSemantic proximity Read

Transcriptional Patterns in Stages of Alzheimer's Disease Are Cell-Type–Specific and Partially Converge with the Effects of Alcohol Use Disorder in HumansSemantic proximity Read

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s diseaseSemantic proximity Read

Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals novel associations with AD pathologySemantic proximity Read

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s diseaseSemantic proximity Read

Single-cell RNA sequencing analysis of human Alzheimer’s disease brain samples reveals neuronal and glial specific cells differential expressionSemantic proximity Read

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer’s diseaseSemantic proximity Read

Accelerated aging-related transcriptome alterations in neurovascular unit cells in the brain of Alzheimer’s diseaseSemantic proximity Read

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's diseaseSemantic proximity Read

Avoiding false discoveries: Revisiting an Alzheimer’s disease snRNA-Seq datasetSemantic proximity Read

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.Semantic proximity Read

Molecular mechanism decipher of Alzheimer’s disease based on single-cell RNA-seq informationSemantic proximity Read