Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative genomic and transcriptomic analysis identifies microglia-expressed genes with causal links to Alzheimer's disease risk.

Journal of Alzheimer's disease : JAD - 1 Jul 2026

Zhao Yuanyuan, Liu Conghui, Yv Keke, Wang Nan, Li Zuowei

Abstract excerpt

BackgroundMicroglia play a central role in Alzheimer's disease (AD) pathogenesis, yet it remains unclear whether microglia-related gene expression changes contribute causally to disease risk or reflect downstream responses to neurodegeneration.ObjectiveThis study aimed to systematically identify microglia-expressed genes with genetically regulated expression associated with AD risk and to characterize their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Genomics

Share to Mendelian Randomization Analysis

Share to Microglia

Share to Transcriptome

Source

Identifiers

PMID: 42227173
DOI: 10.1177/13872877261452242

Genes

BLNK
CASS4
GRN
MS4A4A
SIGLEC11
TSPAN14
USP6NL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative genomic and transcriptomic analysis identifies microglia-expressed genes with causal links to Alzheimer's disease risk.PMID 42227173Read ↗

Regulatory landscape of Alzheimer’s disease variants in human microgliaSemantic proximity Read ↗

Genetics of the human microglia regulome refines Alzheimer’s disease risk lociSemantic proximity Read ↗

Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathwaysSemantic proximity Read ↗

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.Semantic proximity Read ↗

Microglia-specific polygenic risk stratification reveals distinct pathological subtypes in Alzheimer’s diseaseSemantic proximity Read ↗

Cell type-specific enhancer-promoter connectivity maps in the human brain and disease risk associationSemantic proximity Read ↗

Integrative analysis of single-nucleus RNA sequencing and Mendelian randomization to explore novel risk genes for Alzheimer's disease.Semantic proximity Read ↗

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer’s diseaseSemantic proximity Read ↗

Leveraging functional annotations to map rare variants associated with Alzheimer disease with gruyere.Semantic proximity Read ↗

Integration of Alzheimer’s GWAS, 3D genomics, and single-cell CRISPRi non-coding screen implicates causal variants in a microglial enhancer regulating <i>TSPAN14</i>Semantic proximity Read ↗

Leveraging functional annotations to map rare variants associated with Alzheimer’s disease with gruyereSemantic proximity Read ↗

Functional characterization of Alzheimer's disease genetic variants in microglia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.