Article

Codon bias coevolves with longevity

2026-07-01

Abstract excerpt

<title>Abstract</title> <p>Somatic mutations drive carcinogenesis and aging, shortening animal lifespan. Since gene vulnerability strongly depends on the abundance of mutation hotspots, we tested whether negative selection of hypermutable (e.g., CpG-bearing) codons could contribute to the evolution of mammalian longevity. Our studies showed that the CGA codon was significantly more depleted in long-lived than sho...

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Literature Corpus work: dbe8c6fa-c142-560a-8242-1bb6e196b1df
DOI: 10.21203/rs.3.rs-9835155/v1

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