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Article

Codon optimality in cancer.

Oncogene - 1 Nov 2021

Gillen Sarah L, Waldron Joseph A, Bushell Martin

Abstract excerpt

A key characteristic of cancer cells is their increased proliferative capacity, which requires elevated levels of protein synthesis. The process of protein synthesis involves the translation of codons within the mRNA coding sequence into a string of amino acids to form a polypeptide chain. As most amino acids are encoded by multiple codons, the nucleotide sequence of a coding region can vary dramatically without...

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Identifiers

PMID: 34584217
DOI: 10.1038/s41388-021-02022-x
PMCID: PMC8585667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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