Article

Mapping the Inter- and Intra-genic Codon Usage Landscape in <i>Homo sapiens</i>

2025-07-31

Abstract excerpt

Although the genetic code is degenerate, codon selection is non-random and reflects significant functional constraints. Codon usage bias (CUB) acts as a layer of post-transcriptional regulation, influencing mRNA stability, translation kinetics, and co-translational protein folding. While CUB is well-characterized in unicellular organisms, its regulatory scope and functional consequences in humans remain complex an...

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Literature Corpus work: f58938d2-f883-58fe-9ca4-fcb6154b706b
DOI: 10.1101/2025.07.27.667039

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